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Conclusions and Recommendations Key messages for at-risk populations: The EVOKE trial failure does not invalidate GLP-1 agonists for preventionthe epidemiological signal remains strong, and these drugs may provide metabolic and cardiovascular benefits with potential cognitive co-benefits when used for approved indications SS-31s approval establishes precedent for mitochondrial-targeted therapeuticswatch this space for expanded indications Popular biohacker peptides (BPC-157, Dihexa, P21) have essentially no human cognitive evidence

Tirzepatide FDA-approved as Mounjaro for type 2 diabetes (2022) and Zepbound for obesity (2023)

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Van Parijs, J., Broekaert, W.F., Goldstein, I.J., and Peumans, W.J., Planta , 1991, vol

A new glucagon and GLP-1 co-agonist eliminate obesity in rodents